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Humulene is one of the core cannabis terpenes, among limonene, myrcene, and pinene. People also commonly refer to the terpene humulene as caryophyllene.

Besides cannabis, this terpene is also found in clove, hops, sage, ginger, echinacea purpura, basil, and ginseng. It gives beer its famous “hoppy” aroma and taste. It gives ginger, echinacea, and sage their sting!

hops in a mini barrel
hops in a mini barrel

Benefits of Humulene

Studies show humulene contains antibacterial, analgesic, antifungal, pharmacokinetic (appetite-suppressing), and anti-inflammatory properties. Research shows that small amounts can kill the S.aureu s bacteria. Research shows small amounts are effective against the S.aureu s bacteria – as well as Bacteroides fragilis, which causes inflammatory bowel disease (IBD).

2003 study demonstrated that humulene, especially when working with other terpenes and cannabinoids, can help fight tumors and malignant cells.

Many studies explore the effects of humulene and its interactions with compounds that trigger inflammation. They found its anti-inflammatory effects very strong and even comparable to the steroid drug dexamethasone.

fresh cut ginger
fresh cut ginger

Although cannabis and many terpenes are known for the “munchies”, humulene can act as an appetite suppressant. This means some use it to aid with weight loss and other disorders causing excessive hunger.

Some research shows humulene increases the secretion of IL-8, which is a chemokine with many functions. One includes promoting developing new blood vessels (angiogenesis). This could potentially be very helpful for wound healing and more.

It is also often used as a sedative, and plants high in humulene are used in natural antibiotic remedies.

fresh organic bundle of sage
fresh organic bundle of sage


Some strains with high amounts of humulene include Pink Kush, White Widow, Skywalker OG, Girl Scout Cookies, Headband, and Sour Diesel.

These statements have not been evaluated by the Food and Drug Administration. This information and article are not intended to diagnose, treat, cure, or prevent any disease. 

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