Studies suggest that CBD oil treatment can reduce the permeability of intestinal cells. This is great news for people with inflammatory bowel diseases such as Crohn’s disease. CBD helps the body block the absorption of harmful intestinal bacteria. CBD reduces inflammatory hypermotility associated with inflammatory bowel diseases like Crohn’s disease: By inhibiting a liver enzyme that breaks down endocannabinoids, CBD supplementation allows anandamide to exert its natural anti-motility and anti-inflammatory effects. CBD will only affect the inflamed area, leaving healthy areas of the gut untouched. CBD does not bind to CB1 receptors but can activate the receptors by increasing endocannabinoid levels. CBD suppresses muscle contractions induced by a neurotransmitter called ACh. According to a 2013 study on cannabis and Crohn’s, it was found that cannabis can produce clinical benefits like pain reduction, nausea relief, and reduction in overall unpleasant feelings. A 2011 study suggests that Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.